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pentobarbital will decrease the level or influence of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital decreases levels of vandetanib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with potent CYP3A4 inducers; these drugs lessen publicity